Sample Input:	[1kna]
Sample Output (C):	[Single]	[Average]
Sample Output (P):	[Single]	[Average]

Single linkage or Average linkage can be selected for clustering interaction energy grid points to define a cluster (binding site).
Single linkage will result in more elongated clusters, which may be more suitable for indentifying peptide binding sites.
Average linkage tends to results in more spherical clusters suitable for identifying small molecule binding sites.

The sample input file corresponds to the PDB entry 1KNA.

The sample output C corresponds to the processing of the sample input file with Carbon probe and either Single or Average clustering.

One of the two probes can be selected for binding site identification.
The Carbon probe is suitable for identifying small-molecule sites where the binding is dominated by van der Waals interactions.
The Phosphate probe is used to identify binding sites of phosphorylated ligands.
EasyMIFs and Autogrid are two different methods to calculate Molecular Interaction Fields. Easymifs is recommended since autogrid may fail on some proteins.

The sample output P corresponds to the processing of the sample input file with Phosphate probe and either Single or Average clustering.